NeuroVISNEUROTRANSMITTERS ANALYTIC

Spinal Cord Dorsal Horn Microdialysis

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Spinal cord dorsal horn microdialysis technique, used to monitor extracellular levels of transmitter substances in the central nervous system of laboratory animals as a reflection of transmitter release, is based on the ability of neurotransmitters to diffuse in the extracellular fluid from the site of release and to cross a semipermeable dialysis membrane.

Several neurotransmitters in the CNS (e.g. serotonin, norepinephrine, GABA, opioids, substance P), have been proposed to be involved in the pain-alleviating effect of surface of the spinal cord.

We provide the service of spinal cord dorsal horn microdialysis, in the spinal dorsal horn of rats, and the measurement of neurotransmitters.

Preliminary rat spinal cord surgery & microdialysis

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Spinal cord dorsal horn microdialysis procedure

  • Making
    Neuropathic pain
    model
  • Von Frey
    Filament test
  • Microdialysis
    sampling
  • LC-MS/MS
    Analysis

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